Open AccessFactors influencing vertebral bone density after renal transplantation
Author(s) -
Kokado Yukito,
Takahara Shirou,
Ichimaru Naotugu,
Toki Kiyohide,
Kyo Masahiro,
Permpongkosol Sompol,
Kojima Yasuyuki,
Inoue Takasi,
Wang Jiand Ding,
Okuyama Akihíko
Publication year - 2000
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2000.tb02077.x
Subject(s) - medicine , transplantation , bone mineral , urology , creatinine , osteoporosis , kidney transplantation , dialysis , calcitonin , nephrology , parathyroid hormone , hyperparathyroidism , prednisolone , secondary hyperparathyroidism , bone density , surgery , endocrinology , calcium
To improve our understanding of the mechanisms underlying osteoporosis following renal transplantation, we compared bone mineral density (BMD) in 158 transplant recipients and in 293 patients undergoing maintenance hemodialysis with age‐ and sex‐matched normal controls. Observations in graft recipients were made up to several years following transplantation. Dual‐energy X‐ray absorptiometry was used to measure BMD. Correlations with clinical variables including serum concentration of parathyroid hormone (PTH) and steroid therapy were evaluated. Lumbar BMD was lower in transplant patients than in dialysis patients at all ages, and continued to decrease with increasing interval posttransplant until the second year after transplantation. Persistent hyperparathyroidism and daily prednisolone dosage were both associated with decreased BMD. Age and creatinine clearance were independent long‐term predictors of BMD by multiple regression analysis. Treatment of renal graft recipients with calcium and vitamin D supplements or calcitonin may be indicated in the early months after transplantation.