Open AccessRegulation of Globin Gene Expression in Erythroid Cells
Author(s) -
Orkin Stuart H.
Publication year - 1995
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1995.0271e.x
Subject(s) - biology , locus control region , gene , transcription (linguistics) , gene expression , genetics , regulation of gene expression , transcription factor , globin , regulatory sequence , microbiology and biotechnology , promoter , computational biology , linguistics , philosophy
Study of globin gene regulation has served as a useful paradigm for cell‐specific and developmental control of transcription in higher eukaryotic cells. Recent work directed toward the identification and characterization of the cis ‐regulatory elements and transcription factors important for both aspects of control is reviewed. Particular emphasis is placed on the organization and function of globin locus control regions, mechanisms of switching of globin gene expression during development, and functions of the major erythroid‐specific nuclear regulatory proteins.