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Placental Transfer of Rh Antibody (Anti‐D IgG) during Pregnancy
Author(s) -
Pollock Janet M.,
Bowman John M.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb00031.x
Subject(s) - antibody , pregnancy , isoantibodies , placenta , medicine , immunoglobulin g , immunology , obstetrics , andrology , chemistry , fetus , biology , genetics
Abstract Anti‐D levels in blood taken immediately postpartum from Rh‐negative women who have been given antenatal Rh immune globulin and the anti‐D levels in the cord blood of their babies were measured semiquantitatively by a low ionic polybrene Auto Analyzer technique. When both mother and baby were Rh‐negative a comparison of their anti‐D levels was made against the interval between injection of the passive anti‐D and delivery. Mothers' levels decreased as the interval increased, the regression coefficient for 73 maternal sera was ‐0.74. The drop in levels of cord blood was much less than that of the mothers' levels. The regression coefficient was ‐0.294 for 74 cord sera (one set of twins). The marked difference between cord blood and maternal blood levels of anti‐D at delivery supports the hypothesis that the transfer of IgG across the placenta is predominantly from mother to fetus and not from fetus to mother.