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Detection of Platelet Antibodies by a Newly Developed Mixed Agglutination with Platelets
Author(s) -
Shibata Yoichi,
Juji Takeo,
Nishizawa Yaeko,
Sakamoto Hisahiro,
Ozawa Naohiro
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01007.x
Subject(s) - platelet , hemagglutination , agglutination (biology) , antibody , medicine , direct agglutination test , immunology , platelet transfusion , coombs test , hemagglutination tests , isoantibodies , serology
. We have developed a mixed passive haemagglutination test for the detection of platelet antibodies. This test is essentially a combination of a modified test of mixed agglutination and reversed passive haemagglutination. Using this test, platelet allo‐antibodies (HLA antibodies and non‐HLA antibodies) were found to be detected with very high sensitivity in the sera of pregnant women and transfused patients. The platelet crossmatch test was performed for patients who had to receive massive platelet transfusion. There was a good correlation between the result of the crossmatch and clinical platelet recovery.