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Kinetic Studies on the Direct Solid Phase Radioimmunoassay for Hepatitis B Antigen
Author(s) -
Prince Alfred M.,
Jass Dan
Publication year - 1974
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1974.tb02689.x
Subject(s) - radioimmunoassay , incubation , antigen , chromatography , incubation period , chemistry , hepatitis b antigens , medicine , virology , immunology , biochemistry , hepatitis b virus , virus
Abstract. Kinetic studies have revealed the direct solid phase radioimmunoassay for hepatitis B antigen (Ausria, Abbott Laboratories) to be markedly sensitive to incubation temperature. The present 18‐hour room temperature incubation can be reduced to 2 h at 50 °C without loss in test sensitivity. The rapid test is also considerably more specific than that carried out under standard conditions. If licensed, this modification would permit HB Ag screening by RIA to be carried out on labile blood products.