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Phytohemagglutinins – A Survey of Recent Progress
Author(s) -
Dechary J. M.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb04082.x
Subject(s) - phaseolus , ricin , pokeweed mitogen , hemagglutinin (influenza) , concanavalin a , lectin , biochemistry , hemagglutination , biology , chemistry , antibody , botany , immunology , toxin , gene , in vitro
Summary. This paper is a review of recent articles by other investigators on phytohemagglutinins and is by necessity selective in nature. Previously known hemagglutinins of members of the family Leguminosae ( Phaseolus, Soja ) have been purified and some of their physical and chemical properties determined. The mitosis‐stimulating factor of P. vulgaris has been purified and the hemagglutinating component separated from it. Another member of Leguminosae ( Wistaria ) has been found to possess mitogenic and blastogenic properties and the pokeweed mitogen has been isolated and characterized. Concanavalin A, the nonspecific hemagglutinin of jack bean, has been highly purified and its quaternary structure determined. The determination of stereo‐chemical requirements for inhibition studies with hemagglutinins now provides a new tool for the solution of unresolved problems in carbohydrate identification and structure. Toxic proteins have been isolated from several members of the family Euphorbiacae. Ricin B, the toxic, nonhemagglutinating protein of the castor bean has been highly purified and some of its physical properties determined.