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Cold Haemagglutinins Associated with Splenomegaly in New Guinea
Author(s) -
Pitney W. R.,
Thomas H. N.,
Wells J. V.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb01736.x
Subject(s) - cold agglutinin , immunology , new guinea , incidence (geometry) , hemagglutination , medicine , virology , biology , antibody , ethnology , physics , optics , history
Summary. A high incidence of cold haemagglutinins with anti‐i specificity was found in serum samples from patients with massive splenomegaly of uncertain cause in the Watut valley of New Guinea. The samples contained increased concentrations of macroglobulin, 16–33% of which represented cold agglutinin activity. Tropical splenomegaly constitutes another condition in which anti‐i appears in association with hyperplasia of reticulo‐endothelial tissue.