Premium
Effect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery
Author(s) -
FERASATKISH R.,
DABBAGH A.,
ALAVI M.,
MOLLASADEGHI G.,
HYDARPUR E.,
MOGHADAM A. A.,
FARITUS Z. S.,
TOTONCHI M. Z.
Publication year - 2008
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2008.01783.x
Subject(s) - medicine , anesthesia , placebo , analgesic , elective surgery , magnesium , surgery , coronary artery bypass surgery , randomized controlled trial , artery , acute pain , materials science , alternative medicine , pathology , metallurgy
Background: Post‐operative pain control is one of the greatest concerns for both physicians and patients. In this study, the effect of magnesium sulfate (MgSO 4 ) solution infusion on post‐operative pain scores and extubation time in patients undergoing elective coronary artery bypass graft (CABG) surgeries was assessed. Methods: In a double‐blind, randomized, placebo‐controlled clinical trial, 218 patients scheduled for elective CABG were selected and randomly assigned to two groups. After matching inclusion and exclusion criteria for the patients, intravenous MgSO 4 was administered intraoperatively for one group and placebo to the second group. Except for this, all the cases were similar regarding anesthesia and surgery. Results: The MgSO 4 patients were extubated sooner compared with the placebo group. Pain scores reported by the group who received MgSO 4 were less at the 6th, 12th, 18th and 24th hours after the operation; also, they needed less morphine sulfate during this period. Conclusion: The results demonstrated a significantly shortened post‐operative time for extubation and reduced acute post‐operative pain scores by intravenous MgSO 4 infusion during elective CABG surgery.