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Propofol as an induction agent in children: pain on injection and pharmacokinetics
Author(s) -
VALTONEN M.,
IISALO E.,
KANTO J.,
ROSENBERG P.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb02879.x
Subject(s) - propofol , medicine , pharmacokinetics , anesthesia , randomized controlled trial , clinical trial , surgery , pharmacology
The efficacy of lignocaine (1%) mixed with propofol in reducing pain on injection with propofol was studied in 40 children undergoing elective surgery in a double–blind, randomized comparison with glucose (5%). The pharmacokinetics of propofol in a single dose of 2.5 mg/kg was also studied in eight children participating in the same sfudy. Lignocaine (1 mg) significantly reduced pain on injection compared to the control group ( P < 0.001). The induction characteristics of propofol were not affected by the lignocaine, and no undesirable interaction was found between the two drugs. The first–stage elimination half–life (tl/2|3) of propofol in children was shorter (mean 9.3 3.8 (s.d.) min) than the values found in adults. This pharmacokinetic alteration may have clinical significance following repeated administration or continuous infusion of propofol.