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Sheep lung as xenograft oxygenator of human blood: An ex vivo study
Author(s) -
Riquet M.,
LePimpecBarthes F.,
Waldmann T.,
Nataf P.,
Cabrol C.,
Pavie A.,
Eme D.,
Gandjbakhch I.,
Briere J.,
Douguet D.,
Zelter M.
Publication year - 1995
Publication title -
xenotransplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.052
H-Index - 61
eISSN - 1399-3089
pISSN - 0908-665X
DOI - 10.1111/j.1399-3089.1995.tb00063.x
Subject(s) - oxygenator , ex vivo , lung , oxygenation , medicine , blood oxygenation , human lung , artificial lung , hemodynamics , anesthesia , in vivo , biology , cardiopulmonary bypass , microbiology and biotechnology , radiology , functional magnetic resonance imaging
Abstract: In order to study whether sheep lung could be used as a suitable oxygenator for human blood, the left lungs of two groups of five sheep were used in an “isolated perfused working lung model system.” A desaturator was inserted in the circuit and the lung was ventilated with ambient air. The lung was perfused in group 1 with heparinated autologous sheep blood and in group 2 with washed human erythrocytes suspended in buffered gelatin. Blood oxygenation as well as hemodynamics and airway parameters followed similar time course in both groups.