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Viral monitoring and successful treatment of a ganciclovir‐resistant cytomegalovirus infection in a heart transplant recipient
Author(s) -
GarcíaMartínez J.,
Folgueira L.,
Delgado R.,
Hernando S.,
Prieto C.,
Aguado J.M.,
Otero J.R.
Publication year - 2008
Publication title -
transplant infectious disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.69
H-Index - 67
eISSN - 1399-3062
pISSN - 1398-2273
DOI - 10.1111/j.1399-3062.2007.00243.x
Subject(s) - medicine , ganciclovir , cytomegalovirus , cytomegalovirus infection , cytomegalovirus infections , heart transplantation , virology , intensive care medicine , immunology , transplantation , human cytomegalovirus , herpesviridae , virus , viral disease
We reported a ganciclovir (GCV)‐resistant cytomegalovirus (CMV) infection in a heart transplant recipient. Genotypic and phenotypic susceptibility assays demonstrated an A594V mutation in the UL97 phosphotransferase gene and GCV IC 50 >96 μM. Low GCV concentration exposure, immunosuppressive treatment, donor‐positive/recipient‐negative CMV serostatus, viral reactivations within antiviral prophylaxis or treatment, contributed to GCV‐resistant strain selection.