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Hematopoietic stem cell transplantation in Langerhans cell histiocytosis: Case report and review of the literature
Author(s) -
Kesik Vural,
Citak Caglar,
Kismet Erol,
Koseoglu Vedat,
Akyuz Canan
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.00989.x
Subject(s) - medicine , langerhans cell histiocytosis , transplantation , refractory (planetary science) , hematopoietic stem cell transplantation , stem cell , disease , histiocytosis , bone marrow transplantation , surgery , pathology , physics , astrobiology , biology , genetics
The prognosis in children with LCH who do not respond to the conventional therapies is very poor. SCT may be a new approach. However, there are limited data about the results of the transplantations. Herein we report a patient with refractory multisystem LCH who underwent allogeneic bone marrow transplantation and is disease and treatment free 54 months after transplantation. Further studies are required to establish the role of SCT in refractory LCH.