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Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid‐free rabbit anti‐human thymocyte globulin
Author(s) -
Talukdar Anjan,
AshokKumar Chethan,
Farrar Jennifer,
Wilson Patrick,
Janakiramanan Arun,
Tregaskes Mary,
Sindhi Rakesh
Publication year - 2008
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00797.x
Subject(s) - anti thymocyte globulin , immunocompetence , thymocyte , medicine , tacrolimus , lymphocyte subsets , immunology , cytotoxic t cell , liver transplantation , globulin , transplantation , lymphocyte , t lymphocyte , immune system , t cell , biology , in vitro , biochemistry
Multiple measurements of lymphocyte subsets in 91 children treated with steroid‐free tacrolimus, and rabbit anti‐human thymocyte globulin induction demonstrate early reconstitution of T‐cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection‐prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.