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Repopulation of ganciclovir‐resistant cytomegalovirus by wild‐type virus
Author(s) -
Drew W. Lawrence,
Liu Catherine
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01681.x
Subject(s) - ganciclovir , valganciclovir , foscarnet , medicine , cytomegalovirus , discontinuation , virology , repopulation , virus , herpesviridae , viral disease , human cytomegalovirus , biology , genetics , stem cell , haematopoiesis
We report a patient in whom ganciclovir ( GCV )‐resistant cytomegalovirus ( CMV ) was replaced by wild‐type virus after discontinuation of GCV /valganciclovir and review other similar cases. Repopulation by wild‐type virus may occur soon after discontinuation and may be fostered by discontinuing GCV altogether rather than continuing it in combination with foscarnet when treating patients with GCV ‐resistant CMV disease.