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A new indication for pancreas transplantation: high grade pancreatic dysplasia
Author(s) -
Charpentier Kevin P.,
Brentnall Teresa A,
Bronner Mary P,
Byrd David,
Marsh Christopher
Publication year - 2004
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2004.00110.x
Subject(s) - medicine , pancreas transplantation , pancreas , malignancy , transplantation , dysplasia , pancreatectomy , gastroenterology , endocrine system , carcinoma , surgery , hormone , kidney transplantation
Abstract: A 42‐yr‐old male presented with a family history of pancreatic carcinoma inherited an autosomal dominant pattern. The development of endocrine and exocrine pancreatic insufficiency served as early markers for neoplastic transformation. Screening endoscopic ultrasound and ERCP showed abnormalities suggestive of pancreatic dysplasia. Total pancreatectomy was performed and pathology confirmed carcinoma in situ , also known as high‐grade pancreatic ductal dysplasia or Pan IN‐3. The patient's post‐operative course was complicated by life threatening, brittle diabetes. Pancreas transplantation was successfully performed. One year following transplantation, the patient has excellent pancreas graft function. He remains insulin free and has no signs of malignancy. Total pancreatectomy followed by pancreas transplantation is a viable therapeutic option for patients in the dysplastic but still pre‐malignant phase of familial pancreatic adenocarcinoma who develop hypoglycemic unawareness following total pancreatectomy.