Premium
A_16_C haplotype in the Fc ε RI β gene confers a higher risk for atopic asthma in the Indian population
Author(s) -
Sharma S,
Nagarkatti R,
BRao C,
Niphadkar PV,
Vijayan V,
Sharma SK,
Ghosh B
Publication year - 2004
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2004.00333.x
Subject(s) - haplotype , asthma , genotype , cohort , allele , genetics , population , locus (genetics) , biology , immunology , medicine , gene , environmental health
We conducted a case‐control study aimed at identifying polymorphisms and haplotypes in the Fc ε RI β gene associated with asthma and its associated phenotypes such as serum IgE levels. A G/A polymorphism in intron 2, a (CA) n repeat polymorphism in intron 5, and a C/T polymorphism in 3′‐UTR, encompassing a length of 8.74 Kb, were genotyped, and haplotypes were generated for unrelated patients and healthy volunteers in two independent cohorts. A significant association was observed at the level of alleles and genotypes studied with asthma independently in the two cohorts (p < 0.05). A change in CC_AA genotype combination to a non‐CC_AA genotype was associated with reduced risk for asthma. Interestingly, a three‐locus haplotype, A_16_C, was found to be significantly associated with asthma (p = 10 −5 in cohort A and p = 0.004 in cohort B). On the other hand, the haplotype G_18_T was found to be negatively associated with asthma (p = 0.007 in cohort A and p = 0.0004 in cohort B). This is the first study identifying a haplotype A_16_C that predisposes individuals to asthma in the Indian population.