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Chorionic villi sampling for early prenatal diagnosis: an option for the Jewish orthodox community
Author(s) -
Zakut H.,
Zamir R.,
Yemini O.,
Sindel L.,
Kohn G.
Publication year - 1989
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1989.tb02925.x
Subject(s) - chorionic villus sampling , judaism , prenatal diagnosis , chorionic villi , pregnancy , obstetrics , medicine , gynecology , genetics , biology , fetus , philosophy , theology
The Jewish religion permits abortion up to 40 days after conception. To accommodate the Jewish orthodox community, prenatal diagnosis in the eighth gestational week may be a feasible goal with clear benefits. We present our experience with chorionic villus sampling (CVS), wherein out of 144 patients requesting CVS, 125 were found to be suitable for the procedure. Excluding patients with fundal placenta and cervical or uterine myoma, chorionic sampling was successfully performed on 102 out of 106 patients (96.2%) and a chromosome result was available for 98 of those patients (96%). Fetal losses, within 14 days following procedure, were 2 out of 125 (1.6%). No complications were encountered following the procedure. The cytogenetic analysis was improved by culturing CVS fragments for 48 h, after which clearer banding patterns could be observed. One of the CVS preparations, from a 7.2/7‐week‐old embryo was successfully examined. Short‐term (6 days) cultures were used as an additional method for chromosome analysis, to extend and confirm results obtained by the direct method.