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Increased frequency of the apolipoprotein E‐4 isoform in male subjects with multifactorial hypercholesterolemia
Author(s) -
Leren Trond P.,
Bbøresen AnneLise,
Berg Kåre,
Hjermann Ingvar,
Luren Paul
Publication year - 1985
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1985.tb00231.x
Subject(s) - apolipoprotein e , medicine , gene isoform , endocrinology , apolipoprotein b , familial hypercholesterolemia , polymorphism (computer science) , allele , biology , cholesterol , genetics , disease , gene
The apoE polymorphism was studied by two‐dimensional gel electrophoresis in serum samples from 62 male subjects with multifactorial hypercholesterolemia and from 63 normal subjects. The apoE‐4 isoform was significantly more frequent (p<0.02) among the hypercholesterolemic subjects than among the normocholesterolemic controls.