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Complex segregation analysis of the Lp(a)/pre‐ß 1 ‐lipoprotein trait
Author(s) -
Iselius L.,
Dahlén G.,
Faire U. DE,
Lundman T.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb01820.x
Subject(s) - trait , penetrance , genetics , dominance (genetics) , heritability , biology , major gene , quantitative trait locus , gene , phenotype , computer science , programming language
Complex segregation analysis of the LpCaypre‐β 1 ‐lipoprotein trait in 229 nuclear families gave strong evidence for a major gene with complete dominance for pre‐β+and gene frequency q = 0.10. The penetrance is 0.917. There was no evidence for either polygenic heritability or environment common to sibs.