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Fragile sites in human chromosomes I The effect of methionine on the Xq fragile site
Author(s) -
HowardPeebles Patricia N.,
Pryor Johnny C.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00703.x
Subject(s) - chromosomal fragile site , methionine , fragile x , genetics , fragile x syndrome , biology , chromosome , gene , amino acid
The Xq fragile site found in males having non‐specific X‐linked mental retardation was studied by varying the chemical and physical parameters of leukocyte cultures. Methionine was shown to be required for marker expression in both medium 199 and MEM. Banding studies indicated that methionine does not function as a stabilizing factor for the fragile site on Xq.