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Muscular anomalies caused by delayed development in human aneuploidy
Author(s) -
Aziz M. Ashraf
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00679.x
Subject(s) - aneuploidy , genetics , biology , medicine , chromosome , gene
Comprehensive dissections of three infants with trisomy‐13 and three with trisomy‐18 have revealed several muscles which appear to be “abnormal” at the time of birth and shortly thereafter. Careful observations show that the peculiar morphology of these muscles results from delayed development rather than from anatomical malformation. The observations are compared with physiological, pathological and in vitro experimental studies of delayed embryonic development in human aneuploidy.