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Association between TNFA‐308 G/A polymorphism and sensitization to para‐ phenylenediamine: a case–control study
Author(s) -
Blömeke B.,
Brans R.,
Dickel H.,
Bruckner T.,
Erdmann S.,
Heesen M.,
Merk H. F.,
Coenraads P.J.
Publication year - 2009
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2008.01704.x
Subject(s) - odds ratio , sensitization , confidence interval , medicine , case control study , genotype , tumor necrosis factor alpha , allergic contact dermatitis , immunology , logistic regression , gastroenterology , allergy , genetics , biology , gene
Background:  Para ‐phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic contact dermatitis (ACD). The cytokine tumor necrosis factor‐alpha (TNF‐α) plays a key role in contact sensitization. Methods:  In this case–control study, we evaluated the distribution of variations in the regulatory region of the gene for TNF‐α ( TNFA‐308 G/A ) in 181 Caucasian individuals with a history of ACD and sensitization to PPD and 161 individuals with no history of sensitization to PPD. Results:  The frequency of GA or AA TNFA genotypes was significantly higher in individuals sensitized to PPD than in age‐ and gender‐matched controls giving an odds ratio (OR) of 2.16 (95% confidence interval, CI: 1.35–3.47; P  = 0.0016). This relation was even more pronounced when restricting cases to females over 45 years (OR = 3.71; 95% CI: 1.65–8.31; P  = 0.0017) vs younger females (less than or equal to 45 years; OR = 2.41; 95% CI: 1.03–5.65; P  = 0.044) or males (OR = 1.05; 95% CI: 0.449–2.47; P  = 1.0). In addition, a logistic regression model revealed a significant effect for TNFA‐308 AA and AG vs GG genotype (point estimate = 2.152; 95% Wald CI: 1.332–3.477). Conclusions:  These findings suggest a possible role for the TNFA‐308 genetic polymorphism as a susceptibility factor for chemically induced ACD.

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