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Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency
Author(s) -
O'B Hourihane J.,
Rhodes H. L.,
Jones A. M.,
Veys P.,
Connett G. J.
Publication year - 2005
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2005.00752.x
Subject(s) - peanut allergy , medicine , allergy , food allergy , immunology , immunodeficiency , bone marrow transplantation , immunopathology , primary immunodeficiency , bone marrow transplant , bone marrow , immune system , pediatrics
Peanut allergy is a severe and life‐threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy.