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Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma
Author(s) -
Hasselmark L.,
Malmgren R.,
Unge G.,
Zetterström O.
Publication year - 1990
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1990.tb00528.x
Subject(s) - platelet , glutathione peroxidase , glutathione , arachidonic acid , medicine , asthma , oxidative stress , peroxidase , endocrinology , chemistry , selenium , immunology , biochemistry , enzyme , organic chemistry
Platelet glutathione peroxidase (GSH‐Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID‐intolerance. The mean value of GSH‐Px activity in the patients was 47.0±7.1 U/10 11 platelets, which is significantly lower than that of 56.4±12 U/10 11 platelets in the controls ( P < 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH‐Px against oxidative stress and the tentative regulatory function of GSH‐Px in arachidonic acid metabolism.