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Histamine control affects the weal produced by the adjacent diluent control in skin prick tests
Author(s) -
Terho E. O.,
Husman K.,
Kivekäs J.,
Riihimäki H.
Publication year - 1989
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1989.tb00442.x
Subject(s) - histamine , diluent , allergen , chemistry , saline , positive control , allergy , immunology , medicine , nuclear chemistry , traditional medicine
The effect of histamine chloride control (10 mg/ml) on the weal reaction produced by the adjacent test solution (buffered glycerol‐saline diluent control) in skin prick tests was studied among 270 peat workers and 214 lumberjacks. The diluent control was placed on the skin at two test sites: 3–4 cm and 18–19 cm from the site of the histamine control. Prick‐test lancets (Dome/Hollister‐Stier) were used to prick the skin. Weal areas of 6 mm 2 or larger were considered to be positive reactions. In both populations the diluent control caused positive reactions nearly three times more often when the test site was 3–4 cm from the site of the histamine control than when it was 18–19 cm away from the control ( P < 0.001). Similar relationships might be found between histamine control and allergen solutions. This finding should be taken into account in histamine‐based standardization of the results of skin prick tests as well as in biological standardization of allergen solutions.