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Serotonin in nasal secretion
Author(s) -
Tønnesen P.,
Hindberg I.
Publication year - 1988
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1988.tb00905.x
Subject(s) - serotonin , histamine , methacholine , endocrinology , medicine , allergen , allergy , immunology , respiratory disease , receptor , lung
The aim of this study was to investigate the serotonin content in nasal secretion. Histamine‐ and methacholine‐induced nasal secretions were collected during a 5‐min period after challenge in 33 normal subjects. Serotonin was determined radio‐enzymatically and was found in 66% of pure, blown secretions. The median concentration of serotonin in histamine‐ and methacholine‐induced secretions was 6.3 nmol/1 (range < 1.6–52.0) and 2.3 nmol/1 (range 1.6‐140.0) (NS), respectively. The serotonin concentration in allergen‐induced nasal secretions in 7 rhinitis patients was 0.8 to 159 nmol/1, median 10.4 nmol/1 which did not differ from the serotonin levels in the normal subjects. The serotonin concentration in nasal lavage fluids in 5 subjects was low (below the detection limit in 78% of the samples). Further studies of serotonin in patients with nasal hypersecretion are indicated.