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Activity of Allergenic Proteins from Dermatophagoides pteronyssinus
Author(s) -
Wahn U.,
MüullerKrampe B.,
Lind P.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb02676.x
Subject(s) - histamine , allergen , immunoglobulin e , basophil , immunology , basophil activation , antibody , allergy , house dust mite , mite , chemistry , pyroglyphidae , medicine , biology , botany
Two purified allergens from Dermatophagoides pteronyssinus , Dp 42 (identical to P 1 ) and Dp X were studied for their ability to induce histamine release from washed leukocytes and to bind to IgE antibodies from the serum of 27 mite‐sensitive children. Almost all patients were demonstrated to be sensitive to both proteins by both assays. Dp 42 was found to have the highest allergenic activity, releasing histamine from leukocytes at a median concentration 10 times lower than for Dp X. There was a positive correlation between basophil sensitivity to both proteins and allergen specific serum IgE concentrations.