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Inhibitory Effect of Cyclosporin A on Histamine Release from Human Leukocytes and Rat Mast Cells
Author(s) -
Pedersen C.,
Permin H.,
Skov P. Stahl,
Norn S.,
Svenson M.,
Mosbech H.,
Bendtzen K.
Publication year - 1985
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1985.tb02668.x
Subject(s) - histamine , concanavalin a , mast cell , basophil , ionophore , in vitro , pharmacology , liberation , chemistry , immunology , calcium , immunoglobulin e , endocrinology , biology , antibody , biochemistry , organic chemistry
The influence of cyclosporin A (CyA) on human basophil histamine release induced in vitro by specific antigen, anti‐IgE, calcium ionophore A23187, or concanavalin A (Con A) was studied. CyA inhibited the release induced by these four stimulators. It is suggested that the drug acts directly on the target cell, since similar effect was obtained with isolated peritoneal rat mast cells. The basophil histamine release was not changed by a non‐immunosuppressive cyclosporin derivate.