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Fluorescence diagnostics as a guide for demarcation and biopsy of suspected anal cancer
Author(s) -
Kriz Martin,
Hegyi Juraj,
Ruzicka Thomas,
Berking Carola
Publication year - 2012
Publication title -
international journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 93
eISSN - 1365-4632
pISSN - 0011-9059
DOI - 10.1111/j.1365-4632.2011.04951.x
Subject(s) - medicine , malignancy , biopsy , anal cancer , dermatology , disease , cancer , radiology , surgery , pathology
Background Malignant epithelial tumors of the perianal skin are relatively rare however show high recurrence rates. A preoperative precise diagnosis and demarcation of the involved cancerous skin remains challenging but is worthwhile to minimize tissue defects and possible limitations of quality of life. Objectives To show the use of fluorescence diagnostics (FD) in the management of chronic perianal disease. Methods FD was performed using methylaminolevulinate (MAL) for three hours topically followed by visualization with blue light (405 nm). Results We report on two patients in whom FD helped to demarcate the involved tissue or to direct biopsy to ascertain the final diagnosis. In one patient with a history of Bowen′s disease and recurrent anal carcinoma, biopsy showed extramammary Paget’s disease and thus was treated by surgical anoplasty. The other patient had a history of chronic anal eczema, and FD‐directed biopsy could exclude suspected malignancy so that the anal eczema was treated by local therapy. Conclusions FD is a non‐invasive technique which can be used in the perianal region in order to delineate pathologic processes which may reduce the number of surgical interventions.