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Preoperative autologous blood donation for bone marrow harvests: Are we wasting donors' time and blood?
Author(s) -
Mijovic A.,
Britten C.,
Regan F.,
Harrison J.
Publication year - 2006
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1111/j.1365-3148.2005.00635.x
Subject(s) - medicine , autologous blood , bone marrow , blood donations , blood transfusion , wasting , donation , surgery , economics , economic growth
summary . Predeposit autologous blood donation (PAD) is frequently offered to bone marrow donors, but its cost‐effectiveness is dubious. We assessed the impact of PAD and bone marrow donation on transfusion requirements; and the use of donated blood units in a retrospective study of 61 bone marrow donors. The mean haemoglobin (Hb) concentration fell from 12·9 to 11·8 g dL −1 in women who predonated one unit and from 13·2 to 10·9 g dL −1 in those who predonated two units. In men who donated two units of blood, the Hb concentration decreased to 12·9 g dL −1 . Bone marrow harvest led to a further decline in Hb concentration by 2·3 g dL −1 in women and by 2·4 g dL −1 in men. The postharvest Hb fell to ≤9·0 g dL −1 in 39% of female and in 6% of the male donors; all but one of them had predonated blood. The utilization rate of autologous units was 45·6%, with 55% of women and 24% of men receiving autologous blood. In females, 59% of transfused autologous units were given with the donor's Hb of ≥ 9·0 g dL −1 ; overtransfusion was even more apparent in men: 71% units were given with a Hb ≥ 10·0 g dL −1 . PAD in bone marrow donors is associated with high wastage and increases the likelihood of requiring a transfusion. We recommend that PAD should not be routinely offered to bone marrow donors.