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Expression of CD43 Epitopes on NK and T Cells
Author(s) -
HØYSÆETER S.,
JENSEN W.,
POSSUM S.
Publication year - 1994
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1994.tb03486.x
Subject(s) - epitope , cd43 , biology , virology , microbiology and biotechnology , computational biology , immunology , antigen , cd20
CD43 epitope expression was studied with a panel of monoclonal antibodies (MoAbs) by immuno‐histochemistry on freeze sections of lymphoid tissues. The MoAb WEN3 stained most cells weakly in the T areas and scattered splenic red pulp cells strongly, whereas the other MoAbs strongly stained the majority of the cells in the T areas but gave variable staining patterns of cells in the non‐T areas. Flow cytometry on CD4 + and CD8 + T cells (T4 and T8 cells), freshly isolated NK cells and LAK cells showed distinct staining profiles for each cell type, with epitope expression patterns of T8 cells lying between those of T4 cells and NK/LAK cells. T8 cells were split by one of the MoAbs, the NK cells, but not LAK cells, were split by two other MoAbs.