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Accessory Cell Paradox: Monocytes Enhance or Inhibit Lectin‐Mediated Human T‐Lymphocyte Proliferation Depending on the Choice of Mitogen
Author(s) -
KILPATRICK D. C.
Publication year - 1988
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1988.tb02439.x
Subject(s) - lectin , mitogen activated protein kinase , phytohemagglutinins , wheat germ agglutinin , datura stramonium , microbiology and biotechnology , biology , cytotoxicity , cell growth , lymphocyte , concanavalin a , inhibitory postsynaptic potential , t cell , immunology , lymphocyte activation , immune system , biochemistry , signal transduction , in vitro , endocrinology , botany
Monocytes suppressed the mitogenic response of human T lymphocytes to the lectin from Datura stramonium but enhanced the mitogenic response of the same lymphocytes to wheat germ agglutinin under identical culture conditions. The inhibitory action was probably cell‐mediated, but was not the result of cytotoxicity. The stimulative activity could be replaced by cell‐free conditioned medium.