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Effects of nu Gene on the Numbers of Mast Cells in Lymph Nodes
Author(s) -
WLODARSKI K.,
MORRISON K.,
ROSE N. R.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00627.x
Subject(s) - lymph , gene , microbiology and biotechnology , biology , pathology , immunology , medicine , genetics
The total numbers of masl cells (MC) in popliteal lymph nodes of homozygous nude (nu/nu) and phenolypicaily normal, heterozygous (+/nu) BALB/c mice are greater than in normal (+/+) BALB/c mice at approximately 6 months of age. The values obtained from 4‐ to 7‐month‐old (nu/nu) and (+/nu) mice are twice as high as those from 2‐ to 3‐month‐old mice. It is concluded that the thymus does not directly determine the number of MC in lymph nodes, but the presence‐of the nu gene or another gene closely linked to the nu gene regulates the number of MC.‘Nude’ mice infected with hepatitis virus accumulate many more MC than do healthy mice.