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A Chemical Approach to the Mechanism of B‐Lymphocyte Activation
Author(s) -
VIDALGOMEZ J.,
HAMMARSTRÖM L.,
SMITH C. I. E.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00524.x
Subject(s) - hapten , conjugate , antibody , chemistry , lymphocyte , inert , mechanism (biology) , immunology , biology , organic chemistry , mathematical analysis , philosophy , mathematics , epistemology
In an attempt 10 definitively determine whether the pure presentation of haptens (on repetitive, non‐metabolizable carriers) to B lymphocytes triggers differentiation to antibody‐producing cells, dinitrophenyl and trinitrophenyl groups have been covalently coupled to potentially inert carriers (polymethylmethacrylate, chlorinated polyethylene and cellulose). The resulting conjugates (with three different degrees of hapten substitution) are not immunogenic. It is therefore concluded that the pure presentation of haptens to B lymphocytes docs not trigger antibody formation.