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The Effect of HLA Antibodies on Platelet Aggregation
Author(s) -
HOLMLUND G.,
TIILIKAINEN A.,
PENTTINEN K.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00331.x
Subject(s) - antiserum , platelet , antibody , platelet aggregation , antigen , human leukocyte antigen , immunology , immune system , chemistry , medicine
Twelve different HLA antisera, detecting antigens of both A and B series and the superspecificities w4 and w6, were tested for platelet‐aggregating activity in 75 antiserum‐platelet combinations. The correlation between the HLA specificities of the antisera and the aggregating effect on platelets carrying the corresponding antigens was significant ( P = 0.011). Because the platelet aggregation test is being used for screening of circulating immune complexes, falsely positive reactions caused by HLA antibodies must be eliminated by adequate control experiments.