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Complexes in Human Plasma between α 1 ‐Antitrypsin and IgA, and α 1 ‐Antitrypsin and Fibrinogen
Author(s) -
LAURELL C.B.,
THULIN E.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb03802.x
Subject(s) - fibrinogen , dimer , thiol , reagent , chemistry , human plasma , monomer , cysteine , in vivo , biochemistry , biology , chromatography , enzyme , organic chemistry , genetics , polymer
Crossed immunoelectrophoretic analyses revealed that plasma contains a complex between α 1 ‐antitrypsin 1 and IgA. Normally the complex constitutes 1–2% of these proteins. The amount varies mainly with the IgA and to some extent with the α 1 ‐at content of the plasma. The complex is sensitive to thiol reagents and is reduced in vivo by penicillamine. The size of the complex and the amount of reduction products are compatible with the assumption of 1 IgA monomer or dimer per α 1 ‐at molecule. An α 1 ‐at complex with fibrinogen is also a regular plasma constituent. This complex is not susceptible to thiol reagents.