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Amyloid Fibril Protein Subunit,‘Protein AS’: Distribution in Tissue and Serum in Different Clinical Types of Amyloidosis Including that Associated with Myelomatosis and Waldenström's Macroglobulinaemia
Author(s) -
HUSBY G.,
SLETTEN K.,
MICHAELSEN T. E.,
NATVIG J. B.
Publication year - 1973
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1973.tb02048.x
Subject(s) - amyloidosis , amyloid (mycology) , serum amyloid p component , pathology , medicine , proteinuria , amyloid fibril , globulin , protein subunit , chemistry , antibody , immunology , inflammation , biochemistry , c reactive protein , kidney , disease , amyloid β , gene
Gel filtration of degraded amyloid fibrils, derived from patients with different clinical types of amyloidosis, revealed a nonimmunoglobulin protein of low molecular weight (protein AS). This protein was previously found in amyloidosis secondary to chronic inflammation. In this study it was also shown to be present in amyloid connected with certain cases of primary amyloidosis and amyloidosis associated with myelomatosis and Waldenström's macroglobulineamia with Bence‐Jones proteinuria. Furthermore, a serum component with electrophoretic mobility in the alpha‐beta‐globulin region and molecular weight of approximately 100,000 was found to be antigenically related to protein AS. This component was found in sera of patients with amyloidosis and also in patients with other diseases known to be associated with amyloidosis. The antigenic cross reactions demonstrated among different amyloid fibrils may be due to protein AS.