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Lymphocyte, antibody and cytokine responses during concurrent infections between helminths that selectively promote T‐helper‐1 or T‐helper‐2 activity
Author(s) -
HEŘMÁEK J.,
GOYAL P.K.,
WAKELIN D.
Publication year - 1994
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1994.tb00330.x
Subject(s) - biology , trichinella spiralis , immunology , nippostrongylus brasiliensis , antigen , antibody , t helper cell , t lymphocyte , immunity , interleukin 12 , immune system , t cell , in vitro , cytotoxic t cell , biochemistry
SUMMARY The injuence of Trichinella spiralis on infections with Trichuris murk was studied in non‐responder B10. BR mice. Mice infectedonly with T. muris were unable to expel parasites and had many adult worms 35 days later. Infection with 300 larvae of T. spiralis, given seven or 14 (but not 28) days after T. muris, enabled mice to expel up to 90% of T. muris; expulsion of T. spiralis was not altered. Concurrently infected mice produced less T. murisspecijic IgG2a antibody than mice infected with T. muris only, andshowed higher proliferative responses when spleen and mesenteric lymph node cells were cultured in vitro with T. murk antigens. When T. spiralis was present mucosal mast cells were generated in T. muris‐infected mice, whereas almost no mast cells were seen with only T. muris. Lymphocytes from doubly‐infected mice produced significantly more interleukin 4 and 5 (IL‐4, IL‐5) and significantly less interferon‐gamma (IFN‐y) when stimulated in vitro with Concanavalin A (Con‐A) than cells from mice infected with T. murk only. These data demonstrate that BI0.BR mice, which in single infections produce a Thl response to T. muris and develop no protective immunity, can mount a protective T‐helper‐2 (Th2) response and expel T. murk when concurrently infected with the ‘Th2 inducing’ nematode T. spiralis.