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Enhancing and suppressive effects of tumour necrosis factor/cachectin on growth of Trypanosoma musculi
Author(s) -
KONGSHAVN PATRICIA A.L.,
GHADIRIAN ESFANDIAR
Publication year - 1988
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.1988.tb00245.x
Subject(s) - biology , tumor necrosis factor alpha , in vivo , in vitro , parasite hosting , immunology , recombinant dna , population , microbiology and biotechnology , biochemistry , medicine , environmental health , world wide web , computer science , gene
Summary The effect of human recombinant TNF on the growth of T. musculi has been investigated. When added to parasites cultured in vitro , TNF inhibited their growth. In the presence of thioglycollate‐elicited peritoneal exudate cells, the opposite effect was seen and TNF enhanced the growth of trypanosomes in vitro. Similarly, administration of TNF in vivo during the course of infection led to a net increase in the parasite population. It is suggested that TNF exerts a direct anti‐trypanosomal effect while simultaneously promoting the growth of the parasite through an indirect effect mediated via the host's cells, possibly the macrophages.
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