Premium
Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection
Author(s) -
Boche D.,
Gray F.,
Chakrabarti L.,
Hurtrel M.,
Montagnier L.,
Hurtrel B.
Publication year - 1995
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1995.tb01100.x
Subject(s) - pallor , microglia , simian immunodeficiency virus , gliosis , virology , biology , virus , viral replication , pathology , white matter , immunology , medicine , inflammation , radiology , magnetic resonance imaging , surgery
To assess the susceptibility of resident microglia to simian immunodeticiency virus (SIV) infection, we analysed the hrains of rhesus macaques after intracerebral (i.c.1 inoculation of the virus into the central region at 7 days, 1, 2 and 3 months post‐inoculation (p.i.). The brains of animals showed the same moderate neuro‐pathological changes in central, frontal and parietal regions of the brain. characterized by gliosis, microglial nodules, perivascular infiltrates and occasional white matter pallor and similar low numbers of infected cells detected by in situ hybridization. These results, showing that i.c. inoculation did not lead to preferential infection of brain tissue, even near the inoculation point at 7 days p.i., provide evidence for the low susceptibility of resident microglia to SIV replication during the early stages of infection.