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Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs
Author(s) -
Ohno T.,
Kamiyama Y.,
Aihara R.,
Nakabayashi T.,
Mochiki E.,
Asao T.,
Kuwano H.
Publication year - 2006
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2005.00747.x
Subject(s) - ghrelin , stomach , medicine , gastric emptying , duodenum , motility , jejunum , endocrinology , migrating motor complex , enteroendocrine cell , gastrointestinal tract , endocrine system , motor activity , hormone , biology , genetics
Abstract Ghrelin is a peptide that was discovered in endocrine cells of the stomach. However, its action in regulating the fasted and fed motor activity of the digestive tract is not fully understood. In the present study, we examined the effects of an intravenous (i.v.) injection of canine ghrelin on the physiological fasted and fed motor activities in the stomach, duodenum, jejunum and colon of freely moving conscious dogs. An i.v. injection of canine ghrelin released growth hormone in a dose‐dependent manner; however, it did not stimulate the motor activity of the digestive tract in either the fasted or the fed state. Moreover, an i.v. injection of high‐dose canine ghrelin significantly reduced the motility index in the gastric body in the fasted state. Ghrelin did not accelerate gastric emptying, either. These results differ from previous reports dealing with rodents. It is significant that such results were obtained in research with dogs, which are larger animals.