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Regulation by Ca 2+ in the Yersinia low‐Ca 2+ response
Author(s) -
Straley Susan C.,
Plano Gregory V.,
Skrzypek Elźbieta,
Haddix Pryce L.,
Fields Kenneth A.
Publication year - 1993
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1993.tb01644.x
Subject(s) - biology , operon , secretion , signal transduction , microbiology and biotechnology , virulence , downregulation and upregulation , plasmid , membrane protein , flagellum , transcription (linguistics) , effector , response regulator , transport protein , gene , genetics , biochemistry , escherichia coli , bacterial protein , membrane , linguistics , philosophy
Summary The Yersinia low‐Ca 2+ response (LCR) is a regulatory response in which a set of plasmid‐borne operons is transcriptionally regulated at 37°C in response to the presence or absence of mM concentrations of Ca 2+ . LCR‐regulated operons encode secreted proteins with regulatory and virulence roles as well as non‐secreted regulatory proteins and components of the secretion machinery. Downregulation by Ca 2+ is imposed by a signalling cascade that includes secreted proteins and possibly also components of the secretion system and is hypothesized to act on membrane‐bound inductive components. An important rote in LCR induction is played by LcrD, an inner‐membrane protein with homologues in several virulence‐associated and flagella assembly‐related systems in diverse bacterial species. The mechanism of signal transduction in response to Ca 2+ is not known, and the proteins that bind DNA to downregulate transcription have not been identified.
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