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Expression of chitin synthase genes during yeast and hyphal growth phases of Candida albicans
Author(s) -
ChenWu J. L.,
Zwicker J.,
Bowen A. R.,
Robbins P. W.
Publication year - 1992
Publication title -
molecular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 247
eISSN - 1365-2958
pISSN - 0950-382X
DOI - 10.1111/j.1365-2958.1992.tb01494.x
Subject(s) - chitin synthase , biology , candida albicans , chitin , hypha , yeast , cell wall , gene , microbiology and biotechnology , polysaccharide , saccharomyces cerevisiae , gene expression , biochemistry , chitosan
Summary Chitin, the β1,4‐linked polymer of N ‐acetylglucosamine, is a fibrous polysaccharide that in many yeasts helps to maintain the structure of the mother‐bud junction and in filamentous fungi is often the major supporting component of the cell wall. We have previously described a Candida albicans chitin synthase, CHS1. The DNA and derived protein sequences of a second gene, CHS2, are presented and compared with previously published gene sequences. Northern blot analysis shows that strikingly different levels of synthase 1 and 2 expression occur during yeast and hyphal phases of Candida growth.