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A comparison of the sedative effects of three α 2 ‐adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse
Author(s) -
ENGLAND G. C. W.,
CLARKE K. W.,
GOOSSENS L.
Publication year - 1992
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1992.tb01007.x
Subject(s) - detomidine , xylazine , sedation , sedative , horse , anesthesia , body weight , chemistry , medicine , ketamine , biology , paleontology
The sedative effects of a new α 2 ‐adrenoceptor agonist, romifidine, were compared with those of xylazine and detomidine. Five horses were treated with two doses of romifidine (40 μg/kg body weight and 80 μg/kg body weight), two doses of detomidine (10 μg/kg body weight and 20 μg/kg body weight) and one dose of xylazine (1 mg/kg body weight) given by intravenous injection using a Latin‐square design. The dose of 80 μg/kg romifidine appeared equipotent to 1 mg/kg xylazine and 20 μg/kg detornidine, although at these doses both xylazine and detomidine had a shorter action. Detomidine 20 μglkg and xylazine both produced greater lowering of the head and a greater degree of ataxia than romifidine at either dose. Romifidine produced sedation similar to that of the other drug regimes. The effect upon imposed stimuli was similar.