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Comparative benzylpenicillin pharmacokinetics in the dromedary Camelus dromedarius and in sheep
Author(s) -
OUKESSOU M.,
HOSSAINI J.,
ZINEFILALI R.,
TOUTAIN P. L.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00780.x
Subject(s) - benzylpenicillin , pharmacokinetics , zoology , veterinary medicine , distribution (mathematics) , chemistry , antibiotics , pharmacology , biology , medicine , biochemistry , penicillin , mathematical analysis , mathematics
Oukessou, M., Hossaini, J., Zine‐Filali, R. & Toutain, P.L. Comparative benzylpenicillin pharmacokinetics in the dromedary Camelus dromedarius and in sheep. J. vet. Pharmacol. Therap. 13, 298–303. Benzylpenicillin pharmacokinetics were compared in the dromedary Camelus dromedarius (n =5) and in sheep ( n =5) after administration of a single intravenous injection of benzylpenicillin. The data were described by an open three‐compartment model with elimination from the central compartment. Body clearance (Cl b ) was 4.87±0.63 ml/min/kg in the dromedary and 9.17±1.39 ml/min/kg in sheep, the steady‐state volumes of distribution (V ss ) were 0.151±0.023 l/kg and 0.165±0.038 l/kg and the mean residence times (MRT) 27.34±1.38 min and 14.95±4.16 min in the dromedary and in sheep, respectively. It was concluded that benzylpenicillin elimination occurs more slowly in the dromedary dian in sheep and that use of the same dosage regimen for the two ruminant species may lead to significant differences in plasma concentrations and therapeutic efficacy. P. L. Toutain, INRA Station de Pharmacologie‐Toxicologie, 180 chemin de Tournefeuille, Toulouse, France.