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The pharmacokinetics of chloramphenicol in plasma and saliva of dairy cows
Author(s) -
DOTTER A.,
KROKER R.,
ARNOLD D.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00751.x
Subject(s) - chloramphenicol , saliva , pharmacokinetics , chromatography , chemistry , immunoassay , pharmacology , antibiotics , biology , biochemistry , immunology , antibody
In the present study the pharmacokinetics of chloramphenicol were investigated in bovine plasma and saliva. The method of detection of chloramphenicol, a radio‐immunoassay, requires only small sample volumes, no further clean‐up, and a large number of samples can be processed simultaneously. This enabled the collection of a larger number of samples over a longer period of time than in previous studies. The intention was to obtain a complete pharmacokinetic profile of chloramphenicol, to evaluate it according to common open‐compartment models, and to compare it with the results of previous studies. The radio‐immunoassay results were confirmed by analysing a number of samples distributed over the concentration range of interest by a gas‐chromatographic method with electron‐capture detection. The suitability of saliva was evaluated as a possible means of monitoring compliance with the ban on chloramphenicol in the Federal Republic of Germany in milk‐producing animals.