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The effects of alpha 2 adrenoceptor agonists on airway pressure in anaesthetized sheep
Author(s) -
NOLAN A.,
LIVINGSTON A.,
WATERMAN A.
Publication year - 1986
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1986.tb00025.x
Subject(s) - idazoxan , prazosin , clonidine , xylazine , anesthesia , antagonist , yohimbine , tolazoline , histamine , medicine , alpha 2 adrenergic receptor , airway , receptor , ketamine
Xylazine and clonidine, given intravenously, cause an increase in airway pressure in the anaesthetized, ventilated sheep. This increase was dose dependent and was not mediated by histamine, nor was it blocked by the α 1 ‐adrenoceptor antagonist prazosin. However, the increase was abolished by the α 2 ‐adrenoceptor antagonist, idazoxan. When the α 2 ‐adrenoceptor agonists were administered into the cerebrospinal fluid by injection into the cisterna magna there was no increase in airway pressure, although a similar dose given peripherally still produced an effect. These findings would indicate that the increase in airway pressure seen in these sheep, following administration of xylazine and clonidine, was mediated by peripherally located α 2 ‐adrenoceptors.