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The effect of prostaglandin E 1 on motility of the equine gut
Author(s) -
HUNT J. M.,
GERRING E. L.
Publication year - 1985
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1985.tb00940.x
Subject(s) - ileum , jejunum , motility , peristalsis , prostaglandin , medicine , stomach , large intestine , force transducer , small intestine , contraction (grammar) , intestinal motility , zoology , endocrinology , gastroenterology , biology , genetics , physics , acoustics
Hunt, J.M. & Gerring, E.L. The effect of prostaglandin E 1 on motility of the equine gut. J. vet. Pharmacol. Therap. 8, 165–173. Prostaglandin E 1 was infused intravenously (25, 50 and 75ng/kg/min) in three ponies. Changes in gastrointestinal mechanical and electrical activity were recorded from chronically implanted strain‐gauge force transducers and electrodes. Dose‐dependent responses were obtained: there were significant decreases in electrical spiking activity in the stomach, left large colon and small colon, with a corresponding decrease of activity in the left dorsal colon mechanogram. The small intestine was also affected, showing a decrease in both contraction rate and amplitude, which was more marked in the proximal jejunum than in the ileum. There was an association between these changes in gastrointestinal activity and the presence of discomfort and diminished gut sounds. Judith M. Hunt, Department of Veterinary Surgery and Obstetrics, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, U.K.