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Effects of sodium acetate, bicarbonate and lactate on acid‐base status in anaesthetized dogs
Author(s) -
HARTSFIELD SANDEE M.,
THURMON JOHN C.,
CORBIN J. E.,
BENSON G. JOHN,
AIKEN T.
Publication year - 1981
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1981.tb00710.x
Subject(s) - sodium bicarbonate , bicarbonate , sodium lactate , chemistry , base (topology) , sodium , base excess , acid–base homeostasis , sodium acetate , chromatography , biochemistry , medicine , organic chemistry , mathematics , mathematical analysis
Equal doses of sodium acetate, bicarbonate and lactate (6.6 mEq/L) infused intravenously over 30 min into three groups of halothane‐anaesthetized dogs caused changes in acid‐base status. Arterial carbon dioxide tension (P a CO 2 ), pHa, base excess (BE) and standard bicarbonate (SB) increased. Sodium bicarbonate caused the most rapid and greatest changes. The bicarbonate group was significantly different ( P <0.05) from the other groups at 15 and 30 min after the start of infusion for pHa, BE and SB. The greater effects of bicarbonate are due to its production of alkalinization without a requirement for metabolism; acetate and lactate require oxidation to be effective. The acetate and bicarbonate groups were not statistically different at 45 min after the onset of drug infusion, but both had significantly higher SB and BE mean values than the lactate group. AH measurements made after 45 min revealed no significant differences among groups. Thus, after the earlier differences noted above, the three alkalinizers caused similar effects on acid‐base status. P a CO 2 was elevated in all groups, but there were no differences among groups. Cardiovascular effects caused by infusion of the three drugs were minimal.