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In vitro inactivation of endotoxin by polymyxin B and colistin in mastitic milk
Author(s) -
ZIV G.,
HARTMAN I.,
TORTEN M.
Publication year - 1978
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1978.tb00329.x
Subject(s) - polymyxin b , colistin , polymyxin , in vitro , microbiology and biotechnology , limulus amebocyte lysate , escherichia coli , chemistry , limulus , biology , antibiotics , immunology , lipopolysaccharide , biochemistry , paleontology , gene
The in vitro inactivation of crude endotoxins (lipopolysaccharides) of four Escherichia coli strains by polymyxin B and colistin in mastitic milk was investigated utilizing the Limulus amebocyte lysate test. Although minor differences were observed among the endotoxins in respect to susceptibility to inactivation, activity of each was markedly reduced by both drugs.
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